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In a separate filing, Purdue claims that controlled-release oxycodone "provides pain relief in said patient for at least 12 hours after administration. Doctors in the s often would switch their patients to a dosing schedule of once every eight hours when they complained that the duration of action for OxyContin was too short to be only taken twice a day. Purdue's medical director Robert Reder wrote to one doctor in that "OxyContin has been developed for q12h dosing I request that you not use a q8h dosing regimen. One such memo read, "There is no Q8 dosing with OxyContin Los Angeles Times journalists argue using interviews from opioid addiction experts that such high doses of OxyContin spaced 12 hours apart create a combination of agony during opiate withdrawal lower lows and a schedule of reinforcement that relieves this agony, fostering addiction. The chemical structures are very similar, differing only in that Oxycodone has a hydroxy group at carbon codeine has just a hydrogen in its place Oxycodone has a 7,8-dihydro feature. Codeine has a double bond between those two carbons; and Oxycodone has a carbonyl group as in ketones in place of the hydroxyl group of codeine. It is also similar to hydrocodone , differing only in that it has a hydroxyl group at carbon The free base conversion ratios of different salts are: The hydrochloride salt is the basis of most American oxycodone products whilst bitartrate, tartrate, pectinate, terephthalate and phosphate salts are also available in European products. Methyiodide and hydroiodide are mentioned in older European publications. Biosynthesis In terms of biosynthesis, oxycodone has been found naturally in nectar extracts from the orchid family Epipactis helleborine ; together along with another opioid: Many commercial opiate screening tests cross-react appreciably with oxycodone and its metabolites, but chromatographic techniques can easily distinguish oxycodone from other opiates. It was hoped that a thebaine -derived drug would retain the analgesic effects of morphine and heroin with less dependence. Unfortunately, this was ultimately not found to be the case. The first clinical use of the drug was documented in , the year after it was first developed. Theodor Morell , indicate Hitler received repeated injections of "eukodal" oxycodone. Purdue Pharma — a privately held company based in Stamford, Connecticut, developed the prescription painkiller OxyContin. Upon its release in , OxyContin was hailed as a medical breakthrough, a long-lasting narcotic that could help patients suffering from moderate to severe pain. The drug became a blockbuster, and has reportedly generated some thirty-five billion dollars in revenue for Purdue.
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