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A Chinchilla Persian with sea-green eyes As with blue eyes, the color of green eyes does not result simply from the pigmentation of the iris. The green color is caused by the combination of: They were present in south Siberia during the Bronze Age. Hazel Hazel eyes Hazel eye Hazel eyes are due to a combination of Rayleigh scattering and a moderate amount of melanin in the iris' anterior border layer. This is how many people mistake hazel eyes to be amber and vice versa. Definitions of the eye color hazel vary: Red and violet "Red" albino eyes The eyes of people with severe forms of albinism may appear red under certain lighting conditions owing to the extremely low quantities of melanin ,  allowing the blood vessels to show through. In addition, flash photography can sometimes cause a " red-eye effect ", in which the very bright light from a flash reflects off the retina, which is abundantly vascular, causing the pupil to appear red in the photograph. Instead, the copper accumulates in the liver and in other tissues, including the iris of the eye. This results in the formation of Kayser—Fleischer rings , which are dark rings that encircle the periphery of the iris. Yellowing of the sclera the "whites of the eyes" is associated with jaundice ,  and may be symptomatic of liver diseases such as cirrhosis or hepatitis. Aniridia Aniridia is a congenital condition characterized by an extremely underdeveloped iris, which appears absent on superficial examination. Even people with the lightest blue eyes, with no melanin on the front of the iris at all, have dark brown coloration on the back of it, to prevent light from scattering around inside the eye. In those with milder forms of albinism , the color of the iris is typically blue but can vary from blue to brown. In severe forms of albinism, there is no pigment on the back of the iris, and light from inside the eye can pass through the iris to the front. In these cases, the only color seen is the red from the hemoglobin of the blood in the capillaries of the iris. Such albinos have pink eyes, as do albino rabbits, mice, or any other animal with a total lack of melanin. Transillumination defects can almost always be observed during an eye examination due to lack of iridial pigmentation. Because of this, the pupillary reflex is much more pronounced in albino individuals, and this can emphasize the red eye effect in photographs. Heterochromia This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. November An example of complete heterochromia. The subject has one brown eye and one hazel eye. An example of sectoral heterochromia. The subject has a blue iris with a brown section. Heterochromia heterochromia iridum or heterochromia iridis is an eye condition in which one iris is a different color from the other complete heterochromia , or where a part of one iris is a different color from the remainder partial heterochromia or sectoral heterochromia. It is a result of the relative excess or lack of pigment within an iris or part of an iris, which may be inherited or acquired by disease or injury. A number of causes are responsible, including genetic, such as chimerism , Horner's syndrome and Waardenburg syndrome. A chimera can have two different colored eyes just like any two siblings can—because each cell has different eye color genes. A mosaic can have two different colored eyes if the DNA difference happens to be in an eye-color gene. There are many other possible reasons for having two different-colored eyes. For example, the film actor Lee Van Cleef was born with one blue eye and one green eye, a trait that reportedly was common in his family, suggesting that it was a genetic trait. This anomaly, which film producers thought would be disturbing to film audiences, was "corrected" by having Van Cleef wear brown contact lenses. Another hypothesis about heterochromia is that it can result from a viral infection in utero affecting the development of one eye, possibly through some sort of genetic mutation. Occasionally, heterochromia can be a sign of a serious medical condition. A common cause in females with heterochromia is X-inactivation , which can result in a number of heterochromatic traits, such as calico cats. Trauma and certain medications, such as some prostaglandin analogues , can also cause increased pigmentation in one eye.
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