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Definition[ edit ] The American Thoracic Society defines dyspnea as: List of causes of shortness of breath While shortness of breath is generally caused by disorders of the cardiac or respiratory system , other systems such as neurological ,  musculoskeletal , endocrine , hematologic , and psychiatric may be the cause. Pneumothorax Pneumothorax presents typically with pleuritic chest pain of acute onset and shortness of breath not improved with oxygen. Pneumonia The symptoms of pneumonia are fever , productive cough , shortness of breath, and pleuritic chest pain. Treatment, depending on severity of symptoms, typically starts with anticoagulants ; the presence of ominous signs low blood pressure may warrant the use of thrombolytic drugs. Menstruation, particularly if excessive, can contribute to anaemia and to consequential dyspnea in women. Headaches are also a symptom of dyspnea in patients suffering from anaemia. Some patients report a numb sensation in their head, and others have reported blurred vision caused by hypotension behind the eye due to a lack of oxygen and pressure; these patients have also reported severe head pains, many of which lead to permanent brain damage. Symptoms can include loss of concentration, focus, fatigue, language faculty impairment and memory loss. Cardiac tamponade presents with dyspnea, tachycardia, elevated jugular venous pressure, and pulsus paradoxus. It is believed the central processing in the brain compares the afferent and efferent signals; and dyspnea results when a "mismatch" occurs between the two: Afferent neurons significant in dyspnea arise from a large number of sources including the carotid bodies , medulla , lungs , and chest wall. In the lungs, juxtacapillary J receptors are sensitive to pulmonary interstitial edema, while stretch receptors signal bronchoconstriction. Muscle spindles in the chest wall signal the stretch and tension of the respiratory muscles. Thus, poor ventilation leading to hypercapnia , left heart failure leading to interstitial edema impairing gas exchange , asthma causing bronchoconstriction limiting airflow and muscle fatigue leading to ineffective respiratory muscle action could all contribute to a feeling of dyspnea. The most important respiratory muscle is the diaphragm. Other respiratory muscles include the external and internal intercostal muscles , the abdominal muscles and the accessory breathing muscles. As the brain receives its plentiful supply of afferent information relating to ventilation, it is able to compare it to the current level of respiration as determined by the efferent signals. If the level of respiration is inappropriate for the body's status then dyspnea might occur. There is also a psychological component to dyspnea, as some people may become aware of their breathing in such circumstances but not experience the distress typical of dyspnea.
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